|
ovarian neoplasm
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of ovary
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant Neoplasms
|
0.400 |
GenomicAlterations
|
group |
CGI |
|
|
|
|
Ovarian Carcinoma
|
0.330 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of ovary
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
ovarian neoplasm
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer.
|
21103391 |
2010 |
|
ovarian neoplasm
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes.
|
30209015 |
2018 |
|
ovarian neoplasm
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment.
|
30885433 |
2019 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes.
|
30209015 |
2018 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma.
|
25892415 |
2015 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment.
|
30885433 |
2019 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that miR-7 exerts tumor-suppressive effects in hepatocarcinogenesis through the suppression of oncogene CCNE1 expression and suggest a therapeutic application of miR-7 in HCC.
|
24370822 |
2014 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We identified cyclin E1 as a new target of NF90 and found a significant correlation between NF90 and cyclin E1 expression in HCC.
|
25399696 |
2015 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ectopic BTG2 overexpression decreased HCC growth, caused cell cycle arrest at the G1 phase, and downregulated Cyclin D1 and Cyclin E1 protein expression.
|
29441724 |
2018 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, knockdown of cyclin E1 in LINC00470-overexpressed cells abolished its promotive effects on HCC cell proliferation.
|
31612313 |
2020 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We show that expression of new cyclin E1 mRNA variants IN3, Delta4, and Delta5 is associated with retarded proliferation in murine hepatocellular carcinoma.
|
16799991 |
2006 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR-30c-2-3p in regulating the cell proliferation of HCC.
|
30773676 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer.
|
28618963 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recognizing the importance of cyclin E1 overexpression in breast cancer development, these results suggest a CDK2-BRCA1-NPM pathway that coordinately functions in cell growth and tumor progression pathways.
|
15665273 |
2005 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells.
|
25830480 |
2015 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The data from The Cancer Genome Atlas - Cancer Genome further suggested that hsa-miR-195 could negatively regulate the expression of CCNE1 in glioma.
|
30273182 |
2019 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The frequencies of TP53 mutations and amplification of CCNE1 were increased in AAs in the cancer types showing higher levels of chromosomal instability.
|
30300578 |
2018 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclin E1-driven OvCa is characterized with activated polyamine synthesis, which is associated with decreased cancer immunity.
|
31657115 |
2019 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These data suggest that Cyclin E1 expression is Myb dependent in normal and transformed intestinal epithelial cells, consistent with a cell-cycle progression and chromosome instability role in cancer.
|
25934694 |
2015 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recognizing the importance of cyclin E1 overexpression in breast cancer development, these results suggest a CDK2-BRCA1-NPM pathway that coordinately functions in cell growth and tumor progression pathways.
|
15665273 |
2005 |